Description
Curcuminoids are naturally occurring chemical that provides curcumin its yellow hue. It is derived from the underground stem of the East Indian plant known as (Curcuma longa). For many years, this plant has utilized as traditional asian medicine to treat various illnesses. The anti-inflammatory actions of Curcuminoids involves interfering with NF-κB, reducing the inflammatory response of TNF-α-stimulated human endothelial cells. Curcumin acts as a potent anti-inflammatory agent and anti-carcinogenic actions via modulating various signaling molecules. It suppresses a number of key elements in cellular signal transduction pathways pertinent to growth and malignant transformation; it was demonstrated in vitro that curcumin inhibits protein kinases, c-Jun/AP-1 activation, prostaglandin biosynthesis, and the activity and expression of the enzyme cyclooxygenase (COX). It prevents prostaglandin secretion. Curcuminoids markedly suppress the expression of COX-2, IL-1β, IL-1RN, and IL-6. Curcuminoids are widely recognized for their various health benefits, which include anti-oxidant, anti-microbial, hypoglycemic, anti-inflammatory and anticancer activity.
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